Rapid and Efficient Microwave-Assisted Synthesis of Some New Triazol-3-one Derivatives

MENTEŞE E. , ÖZİL M. , Karaoglu S. A. , KAHVECI B.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.50, sa.2, ss.386-390, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Konu: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1002/jhet.946
  • Sayfa Sayıları: ss.386-390


A growing body of literature has shown the effectiveness of using microwaves in chemical reactions. The aim of this study is to demonstrate a rapid and highly efficient synthesis of some new triazol-3-ones via microwave heating using a monomode microwave. Compared with the thermal process, the microwave heating induces a dramatic reduction of the reaction time and improvement of the yields. In this study, rapid N-benzylation and N-acetylation of triazol-3-ones were achieved by microwave irradiation method for the first time. The newly synthesized compounds showed moderate antimicrobial activity against the standard bacterial and fungal organisms tested.