Examination of the Effects of Thiamine and Thiamine Pyrophosphate on Doxorubicin-Induced Experimental Cardiotoxicity

Polat B., Suleyman H., Sener E., Akcay F.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, vol.20, no.2, pp.221-229, 2015 (SCI-Expanded) identifier identifier identifier


Background and Purpose: To investigate the effect of thiamine and thiamine pyrophosphate on doxorubicin-induced cardiotoxicity biochemically and histopathologically and to examine whether doxorubicin cardiotoxicity is related to the conversion of thiamine into thiamine pyrophosphate and inhibition of thiamine pyrophosphokinase (TPK) enzyme.