Examination of the Effects of Thiamine and Thiamine Pyrophosphate on Doxorubicin-Induced Experimental Cardiotoxicity


Polat B., Suleyman H., Sener E., Akcay F.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, vol.20, no.2, pp.221-229, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1177/1074248414552901
  • Title of Journal : JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
  • Page Numbers: pp.221-229

Abstract

Background and Purpose: To investigate the effect of thiamine and thiamine pyrophosphate on doxorubicin-induced cardiotoxicity biochemically and histopathologically and to examine whether doxorubicin cardiotoxicity is related to the conversion of thiamine into thiamine pyrophosphate and inhibition of thiamine pyrophosphokinase (TPK) enzyme.