Examination of the Effects of Thiamine and Thiamine Pyrophosphate on Doxorubicin-Induced Experimental Cardiotoxicity

Polat, B.; Suleyman, Halis; Sener, E.; Akcay, F.

doi:10.1177/1074248414552901

Examination of the Effects of Thiamine and Thiamine Pyrophosphate on Doxorubicin-Induced Experimental Cardiotoxicity

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Polat B., Suleyman H., Sener E., Akcay F.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, vol.20, no.2, pp.221-229, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 20 Issue: 2
Publication Date: 2015
Doi Number: 10.1177/1074248414552901
Journal Name: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.221-229
Recep Tayyip Erdoğan University Affiliated: No

Abstract

Background and Purpose: To investigate the effect of thiamine and thiamine pyrophosphate on doxorubicin-induced cardiotoxicity biochemically and histopathologically and to examine whether doxorubicin cardiotoxicity is related to the conversion of thiamine into thiamine pyrophosphate and inhibition of thiamine pyrophosphokinase (TPK) enzyme.