A COMPARATIVE INVESTIGATION OF THE NEPHROTOXIC EFFECTS OF VARIOUS ANTIHYPERTENSIVE DRUGS IN RATS: BIOCHEMICAL AND HISTOPATHOLOGICAL ANALYSIS

Malkoc I., ALTUNKAYNAK K., TURAN M. I., Gursan N., HACIMÜFTÜOĞLU A., Akcay F., ...More

ACTA MEDICA MEDITERRANEA, vol.30, no.2, pp.515-521, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2014
  • Journal Name: ACTA MEDICA MEDITERRANEA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.515-521
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Aims: Hypertension is known to cause potentially fatal kidney damage. However, it is unclear whether long-term use of antihypertensive drugs establishes any toxic effect on the kidney. This study investigate whether clonidine, methyldopa, rilmenidine, amlodipine and ramipril establish nephrotoxic effects in rats.