Circulating vaspin levels and epicardial adipose tissue thickness are associated with impaired coronary flow reserve in patients with nonalcoholic fatty liver disease


YILMAZ Y., Kurt R., Gurdal A., ÖZEN ALAHDAB Y., Yonal O., Senates E., ...More

ATHEROSCLEROSIS, vol.217, no.1, pp.125-129, 2011 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 217 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.1016/j.atherosclerosis.2011.03.026
  • Journal Name: ATHEROSCLEROSIS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.125-129
  • Keywords: Biomarkers, Epicardial fat thickness, Coronary flow reserve, Adipokines, Nonalcoholic fatty liver disease, METABOLIC SYNDROME, SERUM-LEVELS, CHEST-PAIN, ARTERY, CHEMERIN, WOMEN, ECHOCARDIOGRAPHY, INFLAMMATION, MARKER, RISK

Abstract

Background: Patients with nonalcoholic fatty liver disease (NAFLD) have a reduced coronary flow reserve (CFR) and an increased risk of cardiovascular disease. The fat cells that surround coronary arteries may play a central and underrecognized role in development of cardiovascular disease through the systemic secretion of adipokines. We therefore evaluated the relation of epicardial fat thickness, serum levels of epicardial fat-related adipokines (chemerin and vaspin), and CFR in patients with NAFLD.