Purpose: To investigate the results of dexamethasone (DEX) implant in the treatment of eyes with refractory Behcet posterior uveitis.Methods: A total of 17 eyes of 12 patients with active Behcet posterior uveitis were enrolled in the study. A single intravitreal injection of DEX implant was applied to each eye. Best corrected visual acuity (BCVA), central macular thickness (CMT), vitreous haze score, and intraocular pressure (IOP) were determined, at baseline and control visits of months 1, 3, 6, and 12.Results: The mean BCVA was significantly increased from baseline at each control visit (all p<0.05). The mean CMT and vitreous haze score were significantly decreased from baseline at each control visit (all p<0.05). Three eyes showed IOP spikes requiring topical anti-glaucomatous treatment.Conclusions: A single injection of DEX implant was safe and effective, as an additional treatment to systemic immunomodulatory drugs, in the treatment of refractory Behcet posterior uveitis, for a 6-month period.