The impact of the time interval on in-vitro fertilisation success after failure of the first attempt

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Tekin Y., CEYHAN S. T., KILIC S., KORKMAZ C.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.35, no.4, pp.403-406, 2015 (SCI-Expanded) identifier identifier identifier

Abstract

The impact of the time interval on in-vitro fertilisation success after failure of the first attempt

By:Tekin, YB (Tekin, Y. Bayoglu)[ 1 ] ; Ceyhan, ST (Ceyhan, S. T.)[ 2 ] ; Kilic, S (Kilic, S.)[ 3 ] ; Korkmaz, C (Korkmaz, C.)[ 2 ]

 

JOURNAL OF OBSTETRICS AND GYNAECOLOGY

 

Volume: 35

 

Issue: 4

 

Pages: 403-406

DOI: 10.3109/01443615.2014.960830

Published: MAY 2015

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Abstract

The aim of this study was to identify the optimal time interval for in-vitro fertilisation that would increase treatment success after failure of the first attempt. This retrospective study evaluated 454 consecutive cycles of 227 infertile women who had two consecutive attempts within a 6-month period at an IVF centre. Data were collected on duration of stimulation, consumption of gonadotropin, numbers of retrieved oocytes, mature oocytes, fertilised eggs, good quality embryos on day 3/5 following oocyte retrieval and clinical and ongoing pregnancy. There were significant increases in clinical pregnancy rates at 2-,3- and 4-month intervals. The maximum increase was after two menstrual cycles (p = 0.001). The highest rate of ongoing pregnancy was in women that had the second attempt after the next menstrual cycle following failure of IVF (27.2%). After IVF failure, initiating the next attempt within 2-4 months increases the clinical pregnancy rates.

Keywords

Author Keywords:Attempt; GnRH antagonist; IVF failure; normoresponder; time interval

KeyWords Plus:PROSPECTIVE RANDOMIZED-TRIAL; OVARIAN STIMULATION CYCLES; GNRH ANTAGONIST; PREGNANCY RATES; EMBRYO; IMPLANTATION; GONADOTROPIN; HORMONE; AGONIST; RESPONDERS

The aim of this study was to identify the optimal time interval for in-vitro fertilisation that would increase treatment success after failure of the first attempt. This retrospective study evaluated 454 consecutive cycles of 227 infertile women who had two consecutive attempts within a 6-month period at an IVF centre. Data were collected on duration of stimulation, consumption of gonadotropin, numbers of retrieved oocytes, mature oocytes, fertilised eggs, good quality embryos on day 3/5 following oocyte retrieval and clinical and ongoing pregnancy. There were significant increases in clinical pregnancy rates at 2-,3- and 4-month intervals. The maximum increase was after two menstrual cycles (p = 0.001). The highest rate of ongoing pregnancy was in women that had the second attempt after the next menstrual cycle following failure of IVF (27.2%). After IVF failure, initiating the next attempt within 2-4 months increases the clinical pregnancy rates.