Outcome of 121 patients with renal amyloid a amyloidosis

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Ahbap E., Kara E., Sahutoglu T., Basturk T., Koc Y., Sakacı T., ...Daha Fazla

JOURNAL OF RESEARCH IN MEDICAL SCIENCES, cilt.19, sa.7, ss.644-649, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 7
  • Basım Tarihi: 2014
  • Dergi Adı: JOURNAL OF RESEARCH IN MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.644-649
  • Anahtar Kelimeler: Amyloid A amyloidosis, dialysis, end-stage renal disease, survival, SYSTEMIC AMYLOIDOSIS, RHEUMATOID-ARTHRITIS, SECONDARY, SURVIVAL, KIDNEY, TRANSPLANTATION, INVOLVEMENT, EXPERIENCE, DIALYSIS, DISEASE
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Background: Amyloid A (AA) amyloidosis is a multisystem, progressive and fatal disease. Renal involvement occurs early in the course of AA. We aimed to investigate the etiology, clinical and laboratory features, and outcome of patients with biopsy-proven renal AA amyloidosis. Materials and Methods: A total of 121 patients (male/female: 84/37, mean age 42.6 +/- 14.4 years) were analyzed retrospectively between January of 2001 and May of 2013. Demographic, clinical and laboratory features and outcomes data were obtained from follow-up charts. Results: Familial Mediterranean fever (37.2%) and tuberculosis (24.8%) were the most frequent causes of amyloidosis. Mean serum creatinine and proteinuria at diagnosis were 2.3 +/- 2.1 mg/dL and 6.7 +/- 5.3 g/day, respectively. Sixty-eight (56.2%) patients were started dialysis treatment during the follow-up period. Mean duration of renal survival was 64.7 +/- 6.3 months. Age, serum creatinine and albumin levels were found as predictors of end-stage renal disease. Fifty patients (% 41.3) died during the follow-up period. The mean survival of patients was 88.7 +/- 7.8 months (median: 63 +/- 13.9). 1, 2 and 5 years survival rates of patients were 80.7%, 68.2% and 51.3%, respectively. Older age, male gender, lower levels of body mass index, estimated glomerular filtration rate, serum albumin, calcium, and higher levels of phosphor, intact parathyroid hormone and proteinuria were associated with a higher mortality. Higher serum creatinine, lower albumin, dialysis requirement and short time to dialysis were predictors of mortality. Conclusion: The outcome of patients with AA amyloidosis and renal involvement is poor, particularly in those who had massive proteinuria, severe hypoalbuminemia and dialysis requirement at the outset.