Akademik Veri Yönetim Sistemi
JOURNAL OF SURGICAL RESEARCH, cilt.213, ss.234-242, 2017 (SCI-Expanded, Scopus)
Background: Erdosteine is a mucolytic agent with antioxidant and anti-inflammatory effects. We evaluated the protective effect of erdosteine pretreatment on oleic acid (OA)induced acute lung injury. Materials and methods: Twenty-four male Wistar Albino rats were assigned to four treatments: control (oral saline +50 mu L intravenous [i.v.] saline), OA (oral saline +50 mu L i.v. OA), erdosteine (150 mg/kg oral erdosteine +50 mu L i.v. saline), and OA + erdosteine (150 mg/kg oral erdosteine +50 mu L i.v. OA). Four hours after OA injection, lung tissues were excised for biochemical and histopathologic evaluation. Results: OA treatment increased lung weight and tissue malondialdehyde and protein carbonyl levels, but erdosteine pretreatment significantly suppressed these changes (0.57 +/- 0.1 g, 3.27 +/- 0.48 nmol/mg protein, and 33.57 +/- 4.6 nmol/mg protein, respectively, for OA versus 0.36 +/- 0.02 g, 1.84 +/- 0.15 nmol/mg protein, and 22.10 +/- 2.55 nmol/mg protein, respectively, for OA + erdosteine; P < 0.05 for all). Erdosteine pretreatment increased the activities of the antioxidant enzymes, catalase, and glutathione peroxidase (0.16 +/- 0.03 k/g and 0.3 +/- 0.01 U/mg protein, respectively, for OA versus 0.33 +/- 0.05 k/g and 0.34 +/- 0.01 U/mg protein, respectively, for OA + erdosteine; P < 0.05 for both). Erdosteine pretreatment also significantly decreased the median numbers of intra-alveolar macrophages and intraalveolar and interstitial neutrophils (29.0, 17.0, and 15.0, respectively, for OA versus 12.5, 4.0, and 6.5, respectively, for OA + erdosteine; P < 0.001 for all). Conclusions: Erdosteine pretreatment increased the activities of antioxidant enzymes and decreased macrophage and neutrophil accumulation, thereby ameliorating the inflammatory effects of OA treatment. Erdosteine pretreatment prevents OA-induced oxidative stress and inflammation and protects the lung tissue against acute lung injury. (C) 2017 Elsevier Inc. All rights reserved.