Evaluation of dry eye syndrome in patients with obstructive sleep apnea syndrome based on serum hypoxia-inducible factor 1 alpha (HIF-1α), matrix metalloproteinase 2 (MMP-2), and desmosine levels

OKUTUCU M., Sagir B., ŞAHİN Ü., ARPA M., Yilmaz E., UZUN F., ...Daha Fazla

BMC OPHTHALMOLOGY, cilt.25, sa.1, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1186/s12886-025-04420-1
  • Dergi Adı: BMC OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Purpose To determine changes in dry eye parameters and serum HIF-1 alpha, MMP-2, and desmosine levels in obstructive sleep apnea syndrome (OSAS) and their correlation. Methods This prospective case-control study included 125 patients divided into mild-to-moderate OSAS (n = 40), severe OSAS (n = 46), and control groups (n = 39). Meibomian gland dropout was evaluated with a tomograph and corneal topographer, apnea-hypopnea index (AHI) with polysomnography, and serum HIF-1 alpha, MMP2, and desmosine levels were analyzed using an enzyme-linked immunosorbent assay. Results Serum HIF-1 alpha and MMP2 levels of the participants in the mild-to-moderate and severe OSAS groups were significantly higher, and serum desmosine levels were significantly lower than those in the control group (all p = 0.001). The upper eyelid meibomian gland dropout values were higher in the severe OSAS group than those in the control group (p = 0.001) (Table 1). Lower and total eyelid meibomian gland dropout values of the participants in the severe and mild-to-moderate OSAS groups were higher than those in the control group (all, p = 0,001).The NIKBUTfirst, NIKBUT-average, total eyelid abnormality score, FES, and Oxford scores were not significantly different.The SPEED questionnaire scores of the participants in the severe and mild-to-moderate OSAS groups were higher than those in the control group, and the SPEED questionnaire values of the participants in the severe OSAS group were higher than those in the mild-to-moderate OSAS group (all, p = 0,001).The serum HIF-1 alpha and MMP-2 levels of the participants were positively correlated with the total eyelid meibomian gland dropout values (r = 0,208, p < 0,05 and r = 0,227, p < 0,05, respectively). Conclusions There was a negative correlation between inflammatory mediators (HIF-1 alpha and MMP-2) and meibomian gland dropout in OSAS.This indicates that there are systemic factors involved in the etiopathogenesis of