Design, Synthesis, and Biological Evaluation of Coumarin-Triazole Hybrid Molecules as Potential Antitumor and Pancreatic Lipase Agents

KAHVECİ B., Yilmaz F., Mentese E., ULKER S.

ARCHIV DER PHARMAZIE, cilt.350, sa.8, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 350 Sayı: 8
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/ardp.201600369
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Antitumor, Coumarin, Hybrid molecule, Lipase inhibition, Triazol-3-one, MICROWAVE-ASSISTED SYNTHESIS, TUMOR-CELL-LINES, 1,2,4-TRIAZOLE DERIVATIVES, ANTIFUNGAL ACTIVITY, ANTICANCER AGENTS, ANTIBACTERIAL ACTIVITY, ASSAY, INHIBITORS, APOPTOSIS, PLANTS
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

The design, synthesis, and investigation of antitumor and anti-lipase activities of some coumarin-triazole hybrid molecules are reported. The synthesis of these hybrid molecules was performed under microwave irradiation and conventional heating procedures. The newly synthesized hybrid molecules were investigated as inhibitors against four tumor cell lines (BT20 human breast carcinoma, SK-Mel 128 melanoma, DU-145 prostate carcinoma, and A549 lung carcinoma) and porcine pancreatic lipase (PPL). Most of these compounds showed notable antitumor activities against the tested tumor cell lines, and compounds 8i and 8l showed the best anti-lipase activity of 99.30 +/- 0.56% and 99.85 +/- 1.21%, respectively, at a concentration of 10 mu M.