In this work, we synthesized goldenberry peel extract-copper (II) (Cu2+) ions nanoflower (NFs) and goldenberry fruit extract-copper (II) (Cu2+) ions nanoflower (NFs) examine their antimicrobial properties on the food pathogen (Staphylococcus aureus, Escherichia coli, Aeromonas spp. and Basillus cereus). The main compounds of the goldenberry peel extract (GBPE) and the goldenberry fruit extract (GBFE) were organic components, and the copper (II) (Cu2 +) ions were inorganic components. GBFE-Cu2 + nanoflowers are quite compact, porous, and uniform as compared to GBPE-Cu2+ nanoflowers. Fourier Transform Infrared spectrometry (FT-IR), Scanning Electron Microscopy (SEM), and Energy-Dispersive X-ray (EDX) spectroscopy were used to observe the structures of the NFs. The findings of FT-IR show Cu–O and Cu–N bonds in NFs, which may be an indicator of the development of NFs. Although the antimicrobial actions of GBPE-hNFs and GBFE-hNFs against food pathogens have been confirmed. The prospective pathways of the antimicrobial impacts of hNFs can be negatively / positively charged molecules in plant extracts, which could enhance the reaction between NFs.