Recent studies of nitrogen containing heterocyclic compounds as novel antiviral agents: A review


Mermer A., KELEŞ T. , Sirin Y.

BIOORGANIC CHEMISTRY, vol.114, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 114
  • Publication Date: 2021
  • Doi Number: 10.1016/j.bioorg.2021.105076
  • Title of Journal : BIOORGANIC CHEMISTRY
  • Keywords: N-heterocyclic compound, Antiviral activity, Structure-activity relationship, BIOLOGICAL EVALUATION, MOLECULAR DOCKING, INDOLE-DERIVATIVES, VIRUS, INHIBITORS, MICROWAVE, ANALOGS, DESIGN, DISCOVERY, HYBRIDS

Abstract

N-heterocycles are important, not only because of their abundance, but above all because of their chemical, biological and technical significance. They play an important role in biological investigation such as anticancer, antiinflammatory, antibacterial, antiviral, anti-tumor, antidiabetic, etc. In this study, we focused on examining synthesized some 5- or 6-ring N-heterocyclic compounds that showed the antiviral activity in last 5 years, and investigation of these compounds structure-activity relationship studies. This review will be useful to scientists in research fields of organic synthesis, medicinal chemistry, and pharmacology.