Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats

FIDAN H., SAHIN O., YAVUZ Y., Kilbas A., CETINKAYA Z., ELA Y., ...Daha Fazla

CRITICAL CARE MEDICINE, cilt.35, sa.12, ss.2822-2829, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 12
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1097/01.ccm.0000295588.86982.7d
  • Dergi Adı: CRITICAL CARE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2822-2829
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Objective: Sepsis and ensuing multiorgan failure continue to be the major causes of mortality in intensive care units. Nuclear factor (NF)-kappa B activation is supposed to be one of the targets in the treatment of sepsis. We studied the effectiveness of caffeic phenethyl ester (CAPE), a known NF-kappa B inhibitor, in cecal ligation and puncture (CLP)-induced sepsis and lung injury.