Four species of Salmo are known from the Mediterranean drainages of southern Anatolia. Salmo platycephalus, from the Seyhan drainage, is redescribed. It is distinguished by the markedly flattened upper profile of the head, a marbled colour pattern in specimens larger than about 170 mm SL and 23-25 gill rakers on outer side of first gill arch. Salmo chilo, new species, is described from Akdere Stream (a tributary of Ceyhan River). It is distinguished by a strongly convex dorsal profile of head, a blunt snout, a conspicuously subterminal mouth, with fleshly maxilla and lower lip. Salmo labecula, new species, is described from from Ecemis (in lower Seyhan drainage), Kartoz and Zindan streams (Koprucay drainage). It is distinguished by the absence of red spots on the body in specimens larger than approximately 70 mm SL, and the presence of numerous black spots on middle of flank, and half of upper and lower flank. Salmo opimus, new species, is described from Tekir, Firniz, Gocuksu (Ceyhan drainage) and Alara streams (a costal drainage). It is distinguished by a markedly convex predorsal area in specimens larger than 170 mm SL (reflected by a deeper body in males), a greyish body, with black spots distinct only on anterior part, usually located on upper part of flank, sometimes on back; and with few red spots (13-47), usually organized in three to five irregular longitudinal rows on middle part of flank.