A convenient method for the synthesis of 3,4-dihydroquinazolines from iminoester hydrochlorides via microwave irradiation
JOURNAL OF CHEMICAL RESEARCH, cilt.43, ss.140-143, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43
- Basım Tarihi: 2019
- Doi Numarası: 10.1177/1747519819857513
- Dergi Adı: JOURNAL OF CHEMICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.140-143
- Anahtar Kelimeler: 3,4-dihydroquinazoline, iminoester hydrochlorides, microwave irradiation, QUINAZOLINE DERIVATIVES, RECEPTOR ANTAGONIST, 1,4-DIHYDROQUINAZOLINES, INHIBITION, DISCOVERY
- Recep Tayyip Erdoğan Üniversitesi Adresli: Evet
Özet
This is work presents a simple and practical strategy for the synthesis of 2-substituted-3,4-dihydroquinazolines in which the ring closure reaction of 2-aminobenzylamine with corresponding iminoester hydrochlorides via microwave irradiation allows the formation of the target compounds. Also, the 3,4-quinazoline derivatives were synthesized by conventional heating procedures for comparison in terms of reaction time and yield.