Akademik Veri Yönetim Sistemi
HEALTHCARE, cilt.13, sa.22, 2025 (SCI-Expanded, SSCI, Scopus)
Background: Obesity is a major public health concern that predisposes individuals to metabolic and cardiovascular complications through chronic inflammation. This study aimed to evaluate the associations between non-standard inflammatory and metabolic indices [Systemic immune-inflammation index (SII), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), C-reactive protein/albumin ratio (CRP/Alb), Fibrosis-4 (FIB-4), triglyceride/high-density lipoprotein (TG/HDL), and triglyceride/glucose (TG/Glucose)] and clinical variables in individuals with obesity. Methods: This single-center retrospective study included 298 adults with varying body mass index (BMI) categories followed at Recep Tayyip Erdo & gbreve;an University Training and Research Hospital between February 2023 and February 2024. Demographic, clinical, and laboratory data were collected. Hematological (leukocyte, neutrophil, lymphocyte, monocyte, and platelet) and biochemical [glucose, triglyceride, HDL, albumin, CRP, aspartate aminotransferase (AST), and alanine aminotransferase (ALT)] parameters were analyzed, and derived indices (CRP/Alb, TG/Glucose, FIB-4, and SII) were calculated. Statistical analyses were performed using SPSS 25.0, and p < 0.05 was considered significant. Results: The mean age was 38.9 +/- 11.5 years, and 54% were female. A positive correlation was found between BMI and CRP/Alb (r = 0.145, p = 0.012), whereas age showed a positive correlation with FIB-4 (r = 0.409, p < 0.001) and a negative correlation with SII (r = -0.117, p = 0.044). FIB-4 and SII were negatively correlated (r = -0.294, p < 0.001). TG/HDL and TG/Glucose were higher in men, whereas PLR was higher in women (p < 0.05). CRP/Alb was elevated in diabetes, and FIB-4 was higher in hypertension and hyperlipidemia. Conclusions: Non-invasive inflammatory and metabolic indices were significantly associated with obesity-related parameters. FIB-4, CRP/Alb, and TG/HDL may serve as complementary indicators of metabolic and fibrotic burden, reflecting the inflammatory-metabolic profile of individuals with obesity.