The aim of this study was to determine the solubility of dental cements in artificial saliva of different pH values. A total of 180 specimens-20 specimens (20 mm diameterx1.5 mm thickness) for each dental cement-were prepared. After the specimens were weighed, they were set in the media with different pH values. After 24 hours, 72 hours, seven days, and 28 days, the specimens were taken out, dried in a desiccator, and re-weighed. Percentage of solubility at each time period was calculated as 100 per cent times weight loss divided by the initial weight of the specimen.